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April 1960

The Effect of Dietary Fat in Idiopathic Hyperlipemia with Xanthomatosis

Author Affiliations

Ann Arbor, Mich.

From the Department of Dermatology, Medical School, University of Michigan.

AMA Arch Derm. 1960;81(4):523-526. doi:10.1001/archderm.1960.03730040027006

Considerable attention has recently been given to the effect of various dietary fats on the serum lipid content of man and experimental animals. Normal individuals, as well as patients with coronary artery disease, hypercholesteremia, hyperlipemia, and diabetes mellitus have been studied. Ahrens and co-workers1 have fed diets containing oils varying in degrees of unsaturation to patients who were studied for periods of from four to six months while they were in a metabolic ward. These studies have demonstrated a remarkable correlation between the iodine number of the dietary fat ingested and the change noted in serum cholesterol and phospholipid content. Safflower oil (Iodine number, 137-145) was the most effective of the vegetable oils in causing a change. Bronte-Stewart et al.2 have shown similar results with normal individuals whose serum cholesterol levels were artificially elevated by ingestion of an egg diet. Keys et al.3 have emphasized the importance

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