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April 1960

Treatment of Cutaneous Trichophyton Rubrum Infection with Human Immune Globulin

Author Affiliations

Long Beach, Calif.

From the Medical Service, Dermatology Section, Veterans Administration Hospital, Long Beach, California.

AMA Arch Derm. 1960;81(4):586-590. doi:10.1001/archderm.1960.03730040090016

Our interest in the treatment of cutaneous Trichophyton rubrum infection by injection of λ-globulin was aroused when Shector, et al.1 reported a remarkable therapeutic and laboratory result in a patient so treated. A man, aged 50, had had erythematous, scaling plaques over the neck and upper back and on the right lower abdomen for seven years, which had partially faded during the winter months, but became more pronounced during the summer. Itching was severe enough to awaken him at night. Various locally applied antifungal remedies had failed to cure the disorder. Culture revealed T. rubrum from both plaques. He was given 2.0 ml. of human λ-globulin intramuscularly three times weekly for a total of 12 treatments. Within 48 hours after the first injection, pruritus was relieved and the involved areas became less erythematous. After the second injection, both plaques appeared normal. Three months later, the skin still appeared normal,

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