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April 1960


AMA Arch Derm. 1960;81(4):624-630. doi:10.1001/archderm.1960.03730040128030

Granular Cell Myoblastoma. Presented by Dr. Frederick J. Szymanski and (by invitation) Dr. Betsy Brennan and Dr. Jack M. Fox.  This 24-year-old patient states that for the past year she has developed thickening of the skin of the left second toe. Approximately six months ago she developed an ulcer on the plantar side of the toe. The lesion is not tender.Physical examination shows a slightly larger left second toe which is firm and indurated. On the plantar surface is an ulceration.X-rays of the toes of the left foot are normal. A microscopic section is presented.Histopathology: Histologic sections reveal a marked hyperplasia of the epidermis, which is pseudoepitheliomatous in appearance. Throughout the corium the collagen has been displaced by large granular cells which are diagnostic of the condition known as granular cell myoblastoma.

Discussion  Dr. David W. Kersting, Milwaukee, Wis.: I was indeed surprised to learn that it

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