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May 1960

Electron Microscopic Observations of the Effects of Griseofulvin on Dermatophytes

Author Affiliations

Miami, Fla.

AMA Arch Derm. 1960;81(5):667-680. doi:10.1001/archderm.1960.03730050023005

Before studying the changes griseofulvin induces in Trichophyton organisms, it was necessary to define the normal fine structure of the fungus. No previous study of sections of these organisms has appeared. The preliminary report by Laden and Erickson10 of the internal structure of Epidermophyton floccosum is the only study of its type with a dermatophyte.

Several workers have attempted to visualize fungi in the electron microscope without sectioning the organisms, but these reports demonstrated little that could not be seen with a light microscope.9,11,14,19 In ultrathin sections it was noted that algae (Allomyces) contain many of the most prominent intracellular structures described in animal cells, such as mitochondria with the classical mitochondrial membrane and cristae, as well as an organized cell nucleus with a double-structured nuclear membrane.22,23 No typical ergastoplasm, however, was found in these aquatic phycomycetes. The most recent studies of bacteria reveal a thin cytoplasmic