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May 1960

In Vitro Resistance Studies with Griseofulvin

AMA Arch Derm. 1960;81(5):681-683. doi:10.1001/archderm.1960.03730050037006

Successive generations of all forms of life tend to develop resistance to specific biologic antagonists which are constantly present in the environment.

Griseofulvin is an antifungal antibiotic to which dermatophytes have not been previously exposed, and which has afforded strikingly beneficial results in clinical infections with these organisms. It was considered essential, therefore, to attempt to develop resistance in vitro, in an effort to prognosticate the future therapeutic effectiveness of the drug.

Selected dermatophytes have been exposed to increasing concentrations of griseofulvin and, although only one phase of the study has been completed, the data which have been accumulated are of sufficient interest to justify a preliminary report.

Method of Study  The organisms selected for study were strains of Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton tonsurans, Trichophyton schoenleini, Epidermophyton floccosum, Microsporum audouini, and Microsporum canis, which had not been exposed to griseofulvin.The medium on which the organisms were grown was

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