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May 1960

A Report on Animal Experiments with Griseofulvin: The Griseofulvin Content of Hair

Author Affiliations

Glasgow, Scotland; Stoke Poges, England

Department of Bacteriology, University of Glasgow (Dr. Gentles); Glaxo Laboratories, Ltd., Stoke Poges, England (Mr. Barnes).

AMA Arch Derm. 1960;81(5):703-708. doi:10.1001/archderm.1960.03730050059011

During the early experimental studies of the effect of oral griseofulvin on Microsporum canis ringworm in guinea pigs (Gentles, 1958)4 it was observed that, approximately seven days after the first treatment, the fluorescence under Wood's light had cleared from the base of infected hairs. Microscopic examination showed that the fungus was confined to the fluorescent portion of the hair, and investigation of large numbers of epilated hairs and of hairs cut longitudinally in skin sections revealed that in certain of them, the tips of some of the fungal hyphae were malformed in a manner which was reminiscent of the effect of griseofulvin on susceptible fungi (Fig. 1). Because of this, and because the length of the uninvaded basal portions of the hairs (Fig. 2) corresponded approximately to the growth in length expected during the treatment period, it was postulated that griseofulvin given orally is incorporated in some way in