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May 1960

Effect of Prolonged Griseofulvin Administration on Liver, Hematopoietic System, and Kidney

Author Affiliations


Department of Dermatology (Dr. Livingood, Dr. Brannen, Dr. Orders, and Dr. Kopstein), and Department of Laboratories (Dr. Rebuck), Henry Ford Hospital.

AMA Arch Derm. 1960;81(5):760-765. doi:10.1001/archderm.1960.03730050116020

The isolation of griseofulvin from Penicillium griseofulvum dierckx, accomplished in 1939, by Oxford and his associates,1 was followed by a long silence; during the ensuing eight years, a period which saw the search for antibacterial agents stepped up at an ever-increasing pace, griseofulvin remained on the shelf as just another "failure," because it did not prove active against bacteria. Then, following the isolation by Brian2 of a substance from Penicillium Janczewski which he called "curling factor" because its addition to fungus cultures resulted in shriveling and stunting of fungal hyphae, and following Grove and McGowan's3 studies which showed griseofulvin and the "curling factor" to be the same substance, griseofulvin was used effectively against fungal diseases affecting comestible plants as well as in the treatment of ringworm in cattle. However, in spite of the reports on the successful use of griseofulvin in both horticulture and veterinary medicine, no

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