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May 1960

Clinical Experiences with Griseofulvin

Author Affiliations

Toronto, Canada

From the Division of Dermatology, Department of Medicine, Toronto General Hospital and Department of Medicine (Dermatology) University of Toronto (Dr. Wrong); From the Dermatology Clinic, Hospital for Sick Children, Toronto and Department of Medicine (Dermatology) University of Toronto (Dr. Rogers).

AMA Arch Derm. 1960;81(5):776-778. doi:10.1001/archderm.1960.03730050132024

The advent of griseofulvin in December, 1958, stimulated general interest in the diagnosis and treatment of Trichophyton rubrum infections of hands and feet and also of Microsporum infections of the scalp. For the past 20 years we had been bombarded by so-called "cures" of T. rubrum infections of nails, palms, and soles, all of which proved to be useless in my hands. I saw such patients with a feeling of frustration and had come to the point where I advised that therapy was a waste of time and a needless expense to them.

Since griseofulvin has received some acclaim in the popular press, many patients have presented themselves for treatment. This is not a true increase in the number of patients infected with T. rubrum. However, it is my opinion that T. rubrum infections have been on the increase since World War II. If this is true, it is indeed