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May 1960

The Treatment of Endothrix Trichophyton Infections with Griseofulvin

Author Affiliations

San Antonio, Texas

AMA Arch Derm. 1960;81(5):813-820. doi:10.1001/archderm.1960.03730050169031

Clinical experiences cited in twelve articles1-12 published during the past year established the therapeutic effectiveness of griseofulvin in tinea capitis. The early reports revealed a paucity of patients with Trichophyton endothrix infections so treated. This prompted us to enlarge on our preliminary studies5 in which we obtained apparent cures in 14 T. tonsurans and 4 T. violaceum infections of the scalp.

In our locale, where endothrix Trichophyton infections have been endemic for many years, a large reservoir of catalogued material has been accumulated. Since spontaneous recovery is rare in these infections and earlier known treatment has been largely ineffective, there was adequate material at hand for such a study.

Clinical Material  During the past 10 months 64 patients with endothrix Trichophyton infections of the scalp, skin, and/or nails have been treated with griseofulvin. Remarks will pertain to only 54 of these patients because of inadequate follow-up on 10.

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