Reports of the effectiveness of griseofulvin1-4 in the therapy of dermatophyte infections led to a clinical and mycological study of 71 ringworm patients treated with this antibiotic.
Materials and Methods
From January through September, 1959, the patients with ringworm infections who came to the private offices of Dr. Levin and Dr. Alden were given griseofulvin tablets to be taken orally. Dosages ranged from 250 mg. to 1 gm. a day for periods of one month to six months.The number and types of infection treated were: tinea unguium, 9; tinea corporis, 2; tinea pedis, 1; various combinations of these, 32, and tinea capitis, 27.Cultures were obtained from all of the patients. Primary isolations were made on Sabouraud dextrose agar with cycloheximide (0.5 mg/ml.) and chloramphenicol (0.05 mg/ml.).5
Clinical response in all patients, regardless of their complaint, was favorable. But cure was effected in only 33 (46.5%)
LEVIN HB, ALDEN HS, AJELLO L. Use of Griseofulvin in Office Practice. AMA Arch Derm. 1960;81(5):827–832. doi:10.1001/archderm.1960.03730050183033
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