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May 1960

Griseofulvin in the Treatment of Some Deep Mycoses

Author Affiliations

México, D.F.

Professor of Dermatology, University of Mexico, Department of Dermatology, General Hospital, Mexico City, Mexico.

AMA Arch Derm. 1960;81(5):841-848. doi:10.1001/archderm.1960.03730050197036

Soon after the first reports on griseofulvin therapy of skin mycoses we began to use this new drug in Mexico. Our results on dermatophytoses23 are similar to those of other investigators and they are not the subject of this paper.

The action of griseofulvin on deep mycoses was not or scarcely considered in the early studies, because in in vitro observations, Sporotrichum schenckii and other fungi were found insensitive.3 As deep mycoses are frequent in Mexico we decided, however, to study their response to this therapy. This paper is a preliminary report on this matter.

Griseofulvin, as it is well known, was first isolated by Oxford, Raistrick, and Simonart25 in 1939 as a metabolic product from Penicillium griseofulvum. In 1946, Brian et al.6 described a fungistatic "curlingfactor" obtained from Penicillium janczewskii, and its identity with griseofulvin was established by Grove and McGowan13 the following year.

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