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May 1960

Effect of Griseofulvin on Trichophyton Rubrum and Trichophyton Violaceum Infections: Clinicomycological Correlation of the Mode of Action in Tissues

Author Affiliations

Bombay, India

From the Mycology Research Unit, Department of Dermatology and Venereology, K.E.M. Hospital.; Honorary Dermatologist and Venereologist-in-Charge (Dr. Desai); Laboratory Technician (Miss Bhat and Mr. Choksi).

AMA Arch Derm. 1960;81(5):849-858. doi:10.1001/archderm.1960.03730050205037

Introduction  Griseofulvin has been described as a fungistatic agent in vitro.1,6 Subsequently, the favorable clinical response of the dermatomycosis in animals4,7,8 and humans has been mentioned in preliminary clinical trials.1,2,9 Harvey Blank's study on the viability of a pathogenic fungus after suspending a culture in griseofulvin medium for 15 days was a phenomenon to be reckoned with and has to be explained1. The other relevant item of practical importance in treatment is the mode of effect of the drug. It brings about distortion and turgidity of hyphae, due to the "cell-wall effect." The action of the antibiotic is essentially local and by contact. That no diffusion takes place through the hyphae is clear from the fact that hyphae contiguous to the inhibited zone in culture but themselves not in contact with griseofulvin, develop normally.10 Hence, in this study, besides the evaluation of various dosage schedules