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June 1960

Clinical Evaluation of Triburon in the Topical Treatment of Pyodermas

Author Affiliations


From the Department of Dermatology (Hermann Pinkus, M.D., Chairman), Wayne State University College of Medicine and Detroit Receiving Hospital.

AMA Arch Derm. 1960;81(6):978-979. doi:10.1001/archderm.1960.03730060094021

Triburon is a new bis-quaternary compound derived from β-ionine, which has been found to have high bacteriostatic and moderate bacteriocidal activity against both Gram-positive and Gram-negative organisms. The chemical is a white crystalline powder which is stable on exposure to air and light, and possesses the structural formula shown at the bottom of the page.

In vitro bacteriostatic and bacteriocidal activity were demonstrated by the serial dilution method and by determination of the phenol coefficient, respectively, while in vivo antibacterial activity was shown in mice.* Preliminary studies performed on the antibacterial activity of Triburon in human bacterial infection have shown favorable results.

The present study covers 81 patients treated with the topical application of Triburon* ointment over a five-month period.

Study  Seventy-five cases in which a diagnosis of a primary or secondary pyoderma was made were treated with 0.1% Triburon in a carbowax base, and an additional six cases, in

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