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June 1960


AMA Arch Derm. 1960;81(6):1048-1053. doi:10.1001/archderm.1960.03730060164039

Cold Urticaria. Presented by Dr. George W. Hambrick Jr. and (by invitation) Dr. Ernst Epstein.  A white girl, age 18 years, complained of generalized itching and hives since the age of eight years whenever she was exposed to the cold air. Her lips become swollen when she eats ice cream, and she has fainted several times while swimming when the water was cold and once while at a football game when the weather was cold.The past history is noncontributory. There is no family history of cold sensitivity, although her father has dermographia.

Examination:  Her face is flushed. There is marked dermographia. Exposing her hand for 20 minutes in water at 10 C and at 3 C for three minutes failed to produce swelling. When her body was immersed to nipple level in water at 15 C for eight minutes, urticaria appeared, as well as hypotension, nausea, and faintness.


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