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June 1960


AMA Arch Derm. 1960;81(6):1056-1057. doi:10.1001/archderm.1960.03730060172041

Leucopathia Symmetrica Progressiva Reticularis or Safu. Presented by Dr. Patrick G. Butler  A woman was born in 1920 in Cebu, Philippine Islands, of Spanish-Filipino parents. During adolescence she slowly acquired white spots on the lower legs, and this depigmentation has been progressive and continuous. No treatment has been given.The mother and three sisters have the same condition. Six brothers and apparently all other male members of the family show no signs of it. She has two daughters, aged 13 and 15 years, residing in California. The oldest girl is now developing the disease.The lesions are bilateral but not symmetrically distributed on the lower legs from the proximal third of tibial surface to just above the malleoli. They diminish on the sides and are all but absent on the posterior of the legs. The primary lesion is a leukodermic macule up to 3 mm. in diameter which is surrounded

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