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July 1960

Factors Determining the Skin-Drug-Vehicle Relationship

Author Affiliations

Dallas, Texas

Clinical Instructor in Dermatology, University of Texas Southwestern Medical School

Arch Dermatol. 1960;82(1):24-31. doi:10.1001/archderm.1960.01580010030004

The purpose of this paper is to review and integrate recent findings relative to topical therapy in the related fields of cutaneous physiology and pharmacology. Many new findings and concepts have appeared in the last few years, and it is necessary to assemble all of these important components in order to achieve a clear perspective of the whole.

The Stratum Corneum  Any general approach to topical therapy should start with a consideration of the stratum corneum. Whether it is intact or not is a major dividing line in dermatologic therapy. A consideration of its other physiologic functions and characteristics is important in understanding the effects that may be produced by topical preparations.This amphoteric protein is hygroscopic and softens when it contains sufficient water. This water diffuses from the stratum mucosum, and water may be taken up from the atmosphere under certain conditions. The sweat that accumulates after application of

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