The association of ichthyosiform changes with "lymphoblastoma," Hodgkin's disease in particular, has been only infrequently recorded.1-13 Skin changes usually appear after the first clinical signs of malignancy; rarer, the onset of ichthyotic and malignant changes start together; only exceptionally skin changes precede the first apparent signs of Hodgkin's disease.2
Report of a Case
the patient's father died of carcinoma of rectum at the age of 58.The patient, now aged 28, was first seen in 1953 because of a scaly eruption of the entire skin of two years' duration. At about the same time (in 1951) follicular pustular lesions appeared on the left side of the neck. The clinical picture of the skin was one of ichthyosis nigricans. Alopecia of the same region appeared in 1952. Otherwise the patient was in good health. Routine laboratory investigations were within the limits of normal. Under the appropriate treatment, folliculitis
STEVANOVIĆ DV. Hodgkin's Disease of the Skin: Acquired Ichthyosis Preceding Tumoral and Ulcerating Lesions for Seven Years. AMA Arch Derm. 1960;82(1):96–99. doi:10.1001/archderm.1960.01580010102017
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