To the Editor:—
I appreciate Dr. Wooldridge's kind remarks about me. I agree with him that if progesterone in large doses causes sebaceous gland hyperplasia this does not exclude the possibility that progesterone in small doses has some kind of therapeutic effect in acne, no matter how unexpected and paradoxical such an effect may be. I have not denied this possibility. I also heartily agree with him when he says that "the human body is, after all, certainly the greatest and least understood laboratory."But this is how far I can agree. I certainly cannot go along with the enthusiasm expressed in Dr. Wooldridge's letter about the "perfect demonstration" of progesterone's effectiveness in premenstrual flares of acne as observed by him and others.The trouble is with our not having well-established criteria of this effectiveness. I am most sympathetic with the great difficulties which arise when in such a situation
Rothman S. THE AGED HUMAN SEBACEOUS GLAND-Reply. AMA Arch Derm. 1960;82(1):106–107. doi:10.1001/archderm.1960.01580010112023
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