Pemphigus Foliaceus. Presented by Dr. William E. Clendenning.
A 50-year-old Negro man was admitted to University Hospitals on June 1, 1959, with a threemonth history of a severe, progressive vesicular and bullous dermatitis. The eruption began in the left inguinal region and subsequently became generalized. Initial examination showed a generalized eruption of which the primary lesion appeared to be a vesicle on an erythematous base. Initially the contents of the vesicles were clear but rapidly became turbid. The vesicles extended in arciform and gyrate fashion eventually forming large plaques covered with a thick scale. Nikolsky's sign was negative. There was a musty, foul odor.Initial biopsies revealed subcorneal vesicles filled with acute and chronic inflammatory cells. A diagnosis of subcorneal pustular dermatosis was considered, and the patient was given short trials of Kynex and sulfapyridine without improvement. Further biopsies showed acantholysis of the granular layer more consistent with pemphigus foliaceus
Cole HN, Sato SI, Netherton TE. CLEVELAND DERMATOLOGICAL SOCIETY. AMA Arch Derm. 1960;82(1):109–116. doi:10.1001/archderm.1960.01580010115027
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