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September 1960

The Oral Manifestations of Cyclic (Periodic) Neutropenia: Does Periadenitis Mucosa Necrotica Recurrens (Sutton) Exist? A Need for Revaluation

Author Affiliations


Division of Oral Pathology, University of Minnesota.

Arch Dermatol. 1960;82(3):344-348. doi:10.1001/archderm.1960.01580030038004

Cyclic or periodic neutropenia is an unusual disorder characterized by malaise, fever, oral ulceration with scarring, gingivitis, periodontitis, and disappearance of neutrophils from the blood and bone marrow at approximately 21-day intervals. Frequently, but by no means constantly, other findings include the periodic occurrence of sialorrhea, abdominalgia, headache, arthralgia, cutaneous infections, and conjunctivitis.34 Less than 25 well-documented cases in which oral manifestations are mentioned1-25 are available for study, although an additional number may have been reported under such titles as periadenitis mucosa necrotica recurrens, Sutton's disease, recurring scarring painful aphthae, ulcus neuroticum mucosae oris, chronic aphthae, painful mouth ulceration, etc. Although a periodic recurrent history suggesting cyclic neutropenia has been noted in several cases described under these headings, definitive blood studies were not carried out.

Clinical investigation of the etiology of cyclic neutropenia has been futile. Hormonal factors, long suspected as being responsible for the disease, have been