In 1958, attention was focused on griseofulvin, the first orally administered chemotherapeutic agent effective against dermatophyte infections. The clinical trials1-10 thus far reported leave little doubt as to the curative effect of this antibiotic against tinea capitis, even those cases caused by Microsporum audouini. Little is known, however, concerning the optimal dosage. For example, Blank and Roth1 treated two cases of M. audouini tinea capitis with daily dosages of 1-2 gm. for approximately four weeks. Sternberg et al.8 reported the clinical cures of 18 patients with tinea capitis due to M. audouini in three to nine weeks after any of a wide variety of dosages. Kirk and Ajello3 treated patients with 3 to 17 mg. per pound of body weight daily, some of these for four weeks, others longer. These authors felt that in general they observed better results in those patients who received at least
FRIEDMAN L, DERBES VJ, TROMOVITCH TA. Single Dose Therapy of Tinea Capitis. Arch Dermatol. 1960;82(3):415–418. doi:10.1001/archderm.1960.01580030109015
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