The patient was a 5-year-old girl who was first seen in August of 1959 by Dr. Robert Chapman of Brawley, Calif.
He made a clinical diagnosis of ringworm of the scalp and prescribed griseofulvin in doses of 250 mg. three times a day. One week later there developed a severe dermatitis.
Dr. Chapman referred the child to me and when I saw her on Sept. 3 there was present a severe eruption of the scalp, neck, arms, and legs. This was roughly symmetrical and consisted of a diffuse erythema with edema, vesiculation, and scaling.
With soothing therapy and discontinuance of griseofulvin the eruption quieted down in about three weeks. Local fungicides were begun in the scalp on Sept. 30.
Cultures for fungi were negative on Sept. 3 and Sept. 30.
When the acute dermatitis subsided the scalp eruption was quite compatible with a diagnosis of tinea capitis, although laboratory data
O'Farrell NM. Allergic Reaction to Griseofulvin. Arch Dermatol. 1960;82(3):424. doi:10.1001/archderm.1960.01580030118019
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