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To the Editor:
In March a paper was published in the A.M.A. Archives of Dermatology on the subject of defective protein metabolism in collagen diseases (Tye, M. J., et al.: 2,5-Dihydroxyphenylpyruvic Acid and Collagen Diseases, A.M.A. Arch. Dermat. 81:447, 1960). It described the failure of the authors to confirm the presence of urinary 2,5-dihydroxy-phenylpyruvic acid as originally described by Nishimura.However, by using a slightly modified technique, a group of French investigators recently confirmed the Japanese findings (Bulletin de la Société française de dermatologie, No. 4, October, 1959).I feel that an interest in this line of research should be kept alive.Yours truly
Williamson AR. 2,5-DIHYDROXYPHENYLPYRUVIC ACID AND COLLAGEN DISEASES. Arch Dermatol. 1960;82(3):428. doi:10.1001/archderm.1960.01580030122026
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