Polyarteritis nodosa is said to be more common in men than in women. The basic lesions appear to be of the nature of inflammatory, commonly allergic swellings of the blood vessel walls and are a nonspecific, hypersensitive response to a variety of antigens or stimuli, often, but not invariably, one of bacterial origin, and have also been found to occur in association with the exhibition of such drugs as the sulfonamides and antimalarials (Pulvertaft, 1949).
The condition has been defined by Miller (1949) as a form of necrotizing, inflammatory panarteritis affecting small and medium-sized arteries, accompanied both by signs of systemic infection and by focal symptoms due to the scattered primary arterial lesions, and to the local circulatory disturbances, varying from relative ischemia to gross infarction, which are the cause of presenting symptoms. He also drew attention to the occurrence of a characteristically high polymorphonuclear leukocytosis, a raised blood sedimentation
BELISARIO JC. Cutaneous Manifestations in Polyarteritis (Periarteritis) Nodosa: Report of a Case with Livedo Reticularis. Arch Dermatol. 1960;82(4):526–532. doi:10.1001/archderm.1960.01580040044008
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