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October 1960

Coccidioidal Granulomas of Skin and Conjunctiva Treated with Intravenous Amphotericin B: Report of a Case

Author Affiliations


Arch Dermatol. 1960;82(4):605-608. doi:10.1001/archderm.1960.01580040123021

In the treatment of deep mycotic infections, amphotericin B has been shown to have a wider spectrum of activity than other antifungal agents now available.1 However, the encouraging results reported in the treatment of other deep mycoses2,3 have not been uniformly obtained in the treatment of disseminated coccidioidomycosis.4 Because of the unusual occurrence of coccidioidal granulomas on the conjunctiva and the striking objective clinical and laboratory results obtained during an eightmonth period of treatment, the following case is reported.

Report of Case  In December, 1953, this 32-year-old Negro W.A.C. developed a group of nodules in the skin beneath the right breast two months after a trip through the San Joaquin Valley of California. The same month she was admitted to Letterman Army Hospital for surgical excision of the lesions, and a diagnosis of coccidioidomycosis was established histologically and by culture. She was returned to duty and remained

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