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October 1960

Treatment of Verruca Plana Juvenilis with GammaGlobulin

Author Affiliations

Osaka, Japan

Department of Dermatology, Osaka City University Medical School.

Arch Dermatol. 1960;82(4):640-641. doi:10.1001/archderm.1960.01580040158030

Since 1949 γ-globulin has been used as therapeutic agent in divergent diseases of the skin1-5 but not in the treatment of verruca plana, verruca vulgaris, and molluscum contagiosum. The authors have found γ-globulin efficacious when given intradermally in these conditions. In the present report results obtained in treatment of verruca plana are reported.

"Globulin-BPCJ" prepared by the Blood Plasma Corporation of Japan was used in this study. The preparation is said to contain more than 100 mg/ml. of γ-globulin, 2.25% of glycine, and 0.01% of sodium ethylmercurithiosalicylate. Analysis of several samples in our laboratory revealed an average γ-globulin content of 95.4 mg/ml.

The material was injected by three different methods. Intramuscular injections were given 2 to 12 times weekly in single doses of 0.5 to 1.5 gm., the total dose ranging from 2.1 gm. to 22.75 gm. of γ-globulin. Intralesionally, 1 cc. of the preparation was given two, three,

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