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November 1960

Immunologic Reactions in Psoriasis

Author Affiliations

Palo Alto, Calif.

Department of Dermatology, Stanford University School of Medicine (Drs. Aswaq, Farber, and Moreci), Department of Medical Microbiology, Stanford University School of Medicine (Dr. Raffel).

Arch Dermatol. 1960;82(5):663-666. doi:10.1001/archderm.1960.01580050005001

As in certain other diseases of unknown etiology, the possibility suggests itself that immunologic mechanisms may be involved in the pathogenesis of psoriasis. If this disease were to depend upon an autoimmune or allergic process, it is reasonable to expect that antihuman skin antibodies might be present in the sera of patients with psoriasis. To test for the presence of such antibodies, a specific immunologic procedure, the passive cutaneous anaphylactic (PCA) reaction, was used. This procedure has been shown to be a highly sensitive method for detecting known antigen-antibody interactions.1,2

Materials and Methods 

Specimens.—  Sera were obtained from psoriatic patients and controls under sterile conditions. Punch biopsy specimens were taken under local anesthesia from active psoriatic plaques and from apparently uninvolved skin adjacent to them. Skin specimens and sera from subjects free of psoriasis were obtained from routine surgical cases and from patients with atopic dermatitis. All specimens were

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