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Article
November 1960

Edathamil in the Treatment of Scleroderma and Calcinosis Cutis

Author Affiliations

Ann Arbor, Mich.

From the Department of Dermatology, University of Michigan Medical School.

Arch Dermatol. 1960;82(5):732-736. doi:10.1001/archderm.1960.01580050074009
Abstract

There have been reports in the literature on the effectiveness of chelation therapy with the sodium salts of edathamil (ethylenediaminetetraacetic acid EDTA) in the treatment of scleroderma and calcinosis cutis.6,7,8,10 The intravenous use of the chelating agent resulted in subjective improvement, increased joint mobility, softening of the skin with increased pliability, decrease in dysphagia, and dissolution of large quantities of pathologic calcification in some of the patients treated.

It is our purpose to report on the use of edathamil disodium (Endrate disodium) in 27 patients and to show that it has some usefulness in the treatment of scleroderma, particularly in acrosclerosis.

Pharmacology  Edathamil was synthesized by Bersworth in 1927 and has the formula shown in Figure 1.The term chelate was derived from the Greek word chele meaning claw. By its claw-like action edathamil binds or chelates many metals. The free tetra acid is an insoluble crystalline powder, but

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