Recently, chlorothiazide was employed in a small group of patients for the control of premenstrual flare-ups in acne.1 Because of the promising results, additional patients have been treated with chlorothiazide, and its effects have been compared with those obtained with estrogens. In some instances the 2 drugs have been given alternately with successive menstrual periods; in cases not responding satisfactorily to either agent, the 2 drugs have been simultaneously administered. The results suggest that both chlorothiazide and estrogens are helpful in suppressing premenstrual acne flareups, both when given alone but especially when combined.
The material consisted of 110 private patients in whom premenstrual flare-ups of acne consistently occurred. In many patients it was not possible to evaluate properly the effect of the estrogenic or diuretic agent; when these were eliminated, 55 patients were available for study. Necessarily, all patients were given instructions for cleansing and a mild colloidal sulfur