Diseases which are more or less confined to specific anatomic locations are of special interest. This is particularly true of disorders of the lips because of the possibility of subsequent malignant change.
A number of cheilitides have been welldocumented for many years, but in most cases the etiology is obscure. Actinic cheilitis is a notable exception to the rule. Cheilitis exfoliativa, cheilitis glandularis, and cheilitis glandularis apostematosa are diseases in which the mucous membranes and the associated mucous glands are involved. Sometimes secondary changes, such as lymph stasis and sclerosis, cause hypertrophy. Enlargement of the lips is known as macrocheilia and may be due to various inflammatory or neoplastic processes including hemangioma, lymphangioma, hypertrophy of the labial salivary glands, and recurrent attacks of cellulitis or angioneurotic edema.
Miescher,11 in 1945, reported 6 cases in which the onset was sudden and the course progressive, terminating in chronic enlargement of the
LAYMON CW. Cheilitis Granulomatosa and Melkersson-Rosenthal Syndrome. Arch Dermatol. 1961;83(1):112–118. doi:10.1001/archderm.1961.01580070118013
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