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January 1961

Chloroquine for Chronic Discoid Lupus Erythematosus: Intralesional Injections

Author Affiliations


From the Department of Dermatology and Syphilology, New York University Medical Center (Dr. Marion B. Sulzberger, Chairman), Skin and Cancer Unit, University Hospital.

Arch Dermatol. 1961;83(1):146-148. doi:10.1001/archderm.1961.01580070152018

It is not unusual to see one, or perhaps a few residual lesions of various dermatoses which have failed to respond to an otherwise successful regimen of therapy.1 Examples are the persistent penile plaque of distinctive exudative discoid and lichenoid chronic dermatosis (Sulzberger-Garbe), the single or few persistent lesions of psoriasis, lichen planus, pemphigus, discoid lupus erythematosus, and others.

This report concerns primarily the residual lesions of chronic discoid lupus erythematosus.

It is well known that isolated lesions of chronic discoid lupus erythematosus may be treated by various local applications, e.g., various acids, solid carbon dioxide, and the intralesional injection of gold compounds.2,3 Recently, we became interested in the report of Ottolenghi-Lodigiani,4 on the combined intralesional and oral administration of quinacrine (Atabrine) and the report of Thies,5 on the favorable effects of chloroquine used intralesionally as well as systemically.

For our purposes, chloroquine dichloride, 50 mg.

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