Alopecia areata, more than any other dermatologic condition, lends itself to the evaluation of the effectiveness of intralesional injections of various corticosteroid suspensions. This is particularly true if cases of long duration and extensive hair loss are selected. In such cases, when sites of corticosteroid injection are compared with sites injected with saline alone, the specific action of the steroid is easily observed. Although saline, alone, injected into the scalps of patients with alopecia totalis will give some localized transient hair regrowth in roughly 20% of cases, the hairs so produced are invariably sparser, finer, lighter in color, and of briefer duration than hairs grown in response to a suitable corticosteroid suspension.
Rony and Cohen,1 in 1955, first reported on the use of local injections of hydrocortisone suspensions in scalp lesions of alopecia areata. I feel that this is at present the treatment of choice for circumscribed, relatively small
BERGER RA. Alopecia Areata of Eyebrows— Corticosteroids. Arch Dermatol. 1961;83(1):151–155. doi:10.1001/archderm.1961.01580070157020
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