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Article
February 1961

Features Uncommon to Xeroderma Pigmentosum: Case Report with a Study of 92 Biopsy Specimens

Author Affiliations

CINCINNATI

From the Department of Dermatology and the Department of Pathology, College of Medicine, University of Cincinnati.

Arch Dermatol. 1961;83(2):272-276. doi:10.1001/archderm.1961.01580080102011
Abstract

The classical picture of xeroderma pigmentosum is well known as Kaposi's ``senilitas cutis praecox.'' However, there are forms of this skin reaction where one element may predominate and appear to suggest another and a different type of congenital abnormality. This is not surprising since congenital abnormalities need not be restricted to a single element of the skin. There are so-called angiomatous forms of xeroderma pigmentosum, which usually occur late in the disease. This form is usually characterized by telangiectasia, so-called senile angiomas, and even large vascular tumors. Miescher1 has discussed these eruptive angioblastomatous reactions. Moreover, the vascular reaction in xeroderma pigmentosum is of such importance that Gans and Steigleider2 indicated that this tissue may be the source of a possible primary development for xeroderma pigmentosum. Even in the development of classical features of xeroderma pigmentosum, there is an early, socalled erythematous stage which precedes the hyperpigmentation. Later the

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