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March 1961

Acrodermatitis Enteropathica Without Diarrhea

Author Affiliations


Manchester and Salford Hospital for Skin Diseases, Manchester, England (Benjamin Portnoy, Consultant Dermatologist; Cecil W. Marsden, Senior Registrar).

Arch Dermatol. 1961;83(3):420-424. doi:10.1001/archderm.1961.01580090070008

Acrodermatitis enteropathica was first recognized by Danbolt and Closs4 in 1942, although cases had been previously described in the literature under a variety of titles. Further examples of the condition have been reported by Danbolt,2,3 Bloom and Sobel,1 Hodgson-Jones,7 and Hare and Schlesinger.6 The disease is now accepted as a clinical entity comprising a cutaneous eruption, gastrointestinal symptoms, and disturbances of growth and development (Sulzberger and Baer).10 It has been well summarized by Dillaha et al.,5 who also reported the beneficial effects of diiodohydroxyquin (Diodoquin) by mouth as suggested by Schlomovitz.9 Vedder11 noted the occurrence of the condition in a number of siblings. All authors agree on the presence of recurrent attacks of diarrhea or mucoid stools and an erythematous papulovesicular or pustular rash usually surrounding the orifices and on the hands and feet. Paronychia may also be a feature. Thinning

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