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April 1961

Chronic Urticaria Due to Mold Hypersensitivity: A Study in Cross-Sensitization and Autoerythrocyte Sensitization

Author Affiliations


Department of Dermatology, University of Pennsylvania School of Medicine.

Arch Dermatol. 1961;83(4):549-558. doi:10.1001/archderm.1961.01580100013002

Chronic urticaria, perhaps more than other dermatoses, challenges the physician and patient to find its cause. At times this challenge is met with ease, e.g., in the patient with dermographism, a penicillin reaction, cold allergy, or mastocytosis. Yet at other times the hives remain completely mysterious and capricious despite a wearying series of trial diets, environmental changes, skin tests, and psychotherapy. The causes of urticaria seem legion, and in some patients the elimination of 1 etiologic suspect may be followed by the appearance of 10 new ones. We are therefore prompted to record our studies of a patient with chronic urticaria due to a hypersensitivity so extreme as to enable us to view the disease, as it were, under a "clinical microscope." His exquisite sensitivity permitted us to discern a common causal thread extending throughout his entire history of hives. Thus, it was possible to observe a single basic cause,

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