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April 1961

The Affinity of Hydroxystilbamidine for Psoriatic Lesions

Author Affiliations


From the Department of Pathology, Memorial Hospital.

Arch Dermatol. 1961;83(4):584-586. doi:10.1001/archderm.1961.01580100048006

Recent clinical trials with 2-hydroxystilbamidine isethionate in psoriasis (11 cases) showed that the drug becomes localized in the psoriatic areas, both on the glabrous skin and in the nails. This localization of the drug was revealed by examination of the patients under Wood's light. With this method an intense yellow fluorescence of affected areas could be seen. Gentle scraping of the psoriatic lesions showed that this fluorescence was mainly limited to the scale (Fig. 1). In the nails the fluorescence was apparent in the dystrophic parts only, especially in the abnormal adherent hyponychium.

Examination of the skin, scale, and nail sections by fluorescence microscopy revealed that hydroxystilbamidine was concentrated in the cytoplasm of the parakeratotic cells. The yellowish-white fluorescence, denoting the presence of the drug within these cells, had a diffuse cytoplasmic distribution, but, in addition, there were groups of brightly fluorescent yellow granules in some areas. Slight cytoplasmic and