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April 1961


Arch Dermatol. 1961;83(4):703-705. doi:10.1001/archderm.1961.01580100167032

DNA Autosensitivity. Presented by Dr. Murray B. Levin (by invitation).  A Negro woman, aged 40, had an almost constant eruption of 4½ years' duration, characterized by painful and tender wheals and nodules with a hemorrhagic quality localized to the dorsal surface of hands, forearms, lower one-third of arms, dorsa of feet, legs, and lower one-half of thighs. At times the inflammatory reaction was severe enough to form vesicles and bullae. Previous treatment had consisted of corticosteroids and anti-histamines, but no influence was exerted on the lesions. Several biopsies performed during this period were not contributory. A fresh nodule of 20 hours' duration was totally excised on Jan. 2, 1960. At that time the patient was placed on empirical therapy, consisting of chloroquine, 250 mg. 3 times a day for 7 days, and then 250 mg. daily thereafter. There was a dramatic subsidence of all lesions at the end of one

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