The association of diabetes mellitus with porphyria, first reported in 1949,1 has since been noted by several authors, as has the associated disturbance of iron metabolism and hemochromatosis. It would seem that the metabolic defect of porphyria may actually result in the development of diabetes mellitus due to the disturbance of iron and pyrrole metabolism. Our patient is another example of diabetes mellitus developing after the onset of porphyria cutanea tarda. In our case the time interval between the development of porphyria cutanea tarda and diabetes was 4 years.
Report of a Case
The patient, a 47-year-old white man, first consulted one of us (R. P. F.) on Aug. 8, 1959, because of bullous lesions on the hands and forearms. At that time he stated that these lesions had first appeared in the spring of 1955. He volunteered the information that these lesions were always worse in the summer
BURNHAM TK, FOSNAUGH RP. Porphyria, Diabetes, and Their Relationship: A Case Report. Arch Dermatol. 1961;83(5):717–722. doi:10.1001/archderm.1961.01580110005001
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