[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
May 1961

Bowen's Disease and Its Relationship to Systemic Cancer

Author Affiliations


From the Armed Forces Institute of Pathology.

Associate Professor of Dermatology and Associate Professor of Dermal Pathology, Temple University Medical Center, Philadelphia (Dr. Graham); Chief, Department of Pathology, Armed Forces Institute of Pathology (Dr. Helwig).

Arch Dermatol. 1961;83(5):738-758. doi:10.1001/archderm.1961.01580110026004

Introduction  In 1959 we1 reported a previously unrecognized association of Bowen's disease of the skin with primary internal cancer. This scientific exhibit includes data from a much larger group of patients and supports our initial report.Bowen,2 in 1912, described 2 patients with atypical epithelial proliferation of the skin. Each patient had a chronic solitary lesion composed of lenticular papules resembling a noduloulcerative syphiloderm. Darier,3 in 1914, and Bowen,4 in 1915, described multiple, nonelevated, scaly or crusted plaques as a variety of Bowen's disease. Histologically, these lesions were indistinguishable from those reported originally by Bowen.