The history of lupus erythematosus (L. E.) truly began1 in 1845 with the description by Hebra2 of "seborrhea congestiva," which in modern terminology would be classed as chronic (discoid) L. E. Cazenave,3 in 1851, more fully defined this disease and named it "lupus erythematosus." Prior to these definitive descriptions, cases of the chronic form were described by others under such titles as "érythème centrifuge" by Biett4 in 1828, "flux sebacé" by Rayer5 in 1827, and possibly even the case of "ichthyosis facei" by Bateman6 in 1817. Systemic lupus erythematosus, on the other hand, was described by Kaposi7 in 1872.
Although we have been unable to identify the earliest case recorded, bullous lesions in L. E. have been occasionally reported. Hardaway,8 in 1889, described a patient with systemic lupus erythematosus who demonstrated hemorrhagic crusts on the face (presumably preceded by bullae), and Gray,
TROMOVITCH TA, HYMAN AB. Systemic Lupus Erythematosus with Hemorrhagic Bullae: A Case with L. E. Cells Recovered from the Bullae. Arch Dermatol. 1961;83(6):910–914. doi:10.1001/archderm.1961.01580120022004
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