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June 1961

Trichophyton Tonsurans Infection Resistant to Griseofulvin: A Case Demonstrating Clinical and in Vitro Resistance

Author Affiliations


With the assistance of Norman Cardon, M.D.

Section of Dermatology, Medical Service, Veterans Administration Hospital (Dr. Michaelides; Dr. Sulzberger; Dr. Witten; Dr. Cardon).

The Department of Dermatology and Syphilology, New York University Post-Graduate Medical School (Marion B. Sulzberger, M.D., Chairman) and the Skin and Cancer Unit of the New York University Hospital (Dr. Michaelides; Dr. Rosenthal; Dr. Sulzberger; Dr. Witten).

Arch Dermatol. 1961;83(6):988-990. doi:10.1001/archderm.1961.01580120100025

The clinical effectiveness of griseofulvin in the treatment of many of the superficial fungous diseases of man is now well documented. As with many other modern antimicrobial agents, the development of antibiotic-resistant strains of fungi is an ever-present possibility with griseofulvin also. A recent report1 and our present study show that griseofulvin-resistant strains of fungi may occur or develop in the course of treatment.

Report of a Case  A 33-year-old Negro man was admitted to the Veterans Administration Hospital, Manhattan, Oct. 7, 1959, with a widespread skin eruption consisting, for the most part, of pruritic scaly macules of various sizes and shapes. Many of the lesions were circinate, with flat, scaly, or nonscaly centers and slightly raised, thin, reddish borders. The borders of some of the lesions contained minute vesicles and pustules. The scalp hair was diffusely thin; no broken hairs or well-defined areas of alopecia were evident. There