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June 1961

8-Methoxypsoralen Treatment of MBH Leukoderma

Author Affiliations


Department of Dermatology, Northwestern University Medical School, Chicago, Ill.

Arch Dermatol. 1961;83(6):1003-1004. doi:10.1001/archderm.1961.01580120115029

Bilateral areas of persistent leukoderma1-4 (Fig. 1) resulting from the clinical evaluation of 1% to 10% monobenzyl ether of hydroquinone (MBH) offered an ideal control study for evaluating the effectiveness of 8-methoxypsoralen (8-MOP)* in restoring pigmentation.

Nine Negro male subjects with extensive areas of leukoderma on the flexoral surfaces of both forearms, persisting 21/2 years after MBH, were treated for a total of 8 months. For the first 4 months a 5-day weekly schedule of 30 mg. of 8-MOP was followed after 2 hours by exposure with ultraviolet light (Burdick hot quartz Hospital Model LA640) to the flexoral surface of the right forearm. A target distance of 10 inches with a 10-minute exposure was maintained after the first 2 weeks. For the next 4 months the flexoral surface of the left forearm was exposed to ultraviolet light 5 days weekly in the same manner but without the preceding dose