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June 1961

Fixed Drug Eruption from Chlordiazepoxide

Author Affiliations


Arch Dermatol. 1961;83(6):1010-1011. doi:10.1001/archderm.1961.01580120122034

A 66-year-old housewife was seen for an eruption of 2 months' duration. The sides of the face and left chest presented sharply outlined patches of dermatitis about 3 cm. in diameter. The erythema had a copper-like hue. Slight induration was present.

An acute exacerbation after the dermatitis had been well nearly 6 weeks led to the disclosure of the cause. A sample capsule had been taken. Within 12 hours each site of dermatitis flared up. The drug was chlordiazepoxide.* This event led to an overlooked prescription bottle. Chlordiazepoxide had been taken for 2 months without ill effect, a total of 80 capsules, 10 mg. each. The third refill of 40 capsules, 10 mg. each, coincided with the onset. The persistence for 3 months with only slight remission was governed by the time required to use up the 40 capsules. Inadvertently, the sample capsule had established the causative agent. A complete