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June 1961

Amphotericin B in Disseminated Cutaneous Candidiasis

Author Affiliations


Department of Dermatology (Dr. Everett and Dr. Coffey) and Department of Pediatrics (Dr. Kay), University of Oklahoma Medical Center.

Arch Dermatol. 1961;83(6):1014-1015. doi:10.1001/archderm.1961.01580120126036

Generalized cutaneous candidiasis is a comparatively rare chronic infection usually involving the face, ears, neck, upper chest, and mouth. The infection occurs in prepubertal children, and often there are associated ectodermal abnormalities. There is a tendency to form thick, dry, brownish crusts with only a mild inflammatory reaction. Mycelia and spores are invariably present in the lesions. Treatment of this condition has been unsatisfactory, and the outcome is usually fatal.1,2

Recently there have been several reports on the use of amphotericin B in the treatment of systemic candidiasis, a condition which is most often encountered in patients who have received steroid and antibiotic therapy and in patients who have undergone intestinal surgery.3,4 This agent has been moderately successful except in cases in which there was endocarditis or central nervous system involvement.4,5 In some cases there has been apparent biologic cure.4-6 To our knowledge the use of

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