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July 1961

Evaluation of Flurandrenolone: A New Topical Corticosteroid

Author Affiliations


From the Department of Dermato-Syphilology, Marion County General Hospital (Chairman, Boynton H. Booth, M.D.).

Arch Dermatol. 1961;84(1):18-21. doi:10.1001/archderm.1961.01580130024003

Flurandrenolone* is a new corticosteroid which has a chemical formula of 6α-fluoro-16α-hydroxyhydrocortisone-16,17-acetonide. This new steroid is distinguished from hydrocortisone by the presence of 2 activityenhancing groupings, a 6α-fluorine and a 16α-OH. The structural formula follows:

Substitution of an alpha-fluorine atom for hydrogen at the sixth position and a hydroxyl group at the 16α position, as well as the acetonide function linkage at both the 16α- and 17α-hydroxyl groups, are new substituents designed to impart maximum potency as an anti-inflammatory agent. At the same time, the salt-retaining property of the parent compound is decreased.1

Pharmacological animal data by Kraay confirmed this increased potency and decreased sodium retention.2 Flurandrenolone was assayed using the standard methods of thymus involution and inhibition of granuloma formation around a cellulose pellet in adrenalectomized rats. On the basis of thymus involution, flurandrenolone appeared to have about 10 times the oral potency of prednisolone and from