In the hope that an uncommon view of a common disease might afford new insight, we have closely observed 2 cases of psoriasis in the rare acute pustular phase. We believe that in such generalized pustular psoriasis one can see an enormous magnification, acceleration, and accentuation of what otherwise is a slow, insidious, chronic scaling process. Our observations underscore the belief that the leukocytes must play a significant role in the pathogenesis of this disease, both in its classical micropustular and in its rare macropustular form.
Report of Cases
One week prior to hospital admission, this 58-year-old woman had developed an acute exacerbation of her long-standing psoriasis. She had had recalcitrant generalized psoriasis for over 16 years, requiring hospitalization on 3 previous occasions. The present attack began as erythematosquamous lesions of her arms and legs. It rapidly spread within a day to involve the chest and back.On examination
SHELLEY WB, KIRSCHBAUM JO. Generalized Pustular Psoriasis. Arch Dermatol. 1961;84(1):73–78. doi:10.1001/archderm.1961.01580130079011
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