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July 1961

Pyridoxine in the Treatment of Herpes Gestationis

Author Affiliations


From the Department of Dermatology (Clarence S. Livingood, M.D., Chairman) Henry Ford Hospital.

Arch Dermatol. 1961;84(1):90-95. doi:10.1001/archderm.1961.01580130096014

We have observed definite control of the subjective and objective manifestations of herpes gestationis treated with pyridoxine. The beneficial effect of vitamin B6 in herpes gestationis was first observed by us when a patient with herpes gestationis developed nausea of pregnancy.

The purpose of this report is to bring this mode of treatment to the attention of physicians treating this disease and to point out certain laboratory studies which may prove helpful in elucidating the abnormal physiology in herpes gestationis.

In the following case reports, pyridoxine was administered intramuscularly, intravenously, and orally in dosages of from 50 to 300 mg. daily. More rapid improvement occurred when the drug was administered parenterally.

Report of Cases 

Case 1.—  A 24-year-old white female nurse, Gravida I, Para O, was seen early in her third month of pregnancy. Her chief complaint was generalized pruritus. Her only objective findings initially were a patchy erythema and