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July 1961


Arch Dermatol. 1961;84(1):150-155. doi:10.1001/archderm.1961.01580130156031

Eosinophilic Granuloma of the Skin (Granuloma Faciale). Presented by Norman E. Levan, M.D.  The patient is a 51-year-old white housewife who is presented because of a lesion, noted for about 2 months, on the left cheek. There are no accompanying symptoms.The presenting lesion is a slightly elevated, brown, oval, 6 mm. plaque on the left cheek. A histologic specimen shows the epidermis to be essentially normal except for slight hyperkeratosis and some flattening of the rete pegs. There is a narrow zone of normal corium immediately below the epidermis, and below this a dense infiltrate, chiefly perivascular and somewhat focal in character. This infiltrate is polymorphous with numerous eosinophils as well as small lymphocytes, polymorphonuclear leukocytes, and a few histiocytes.

Discussion  S. William Becker, M.D.: Dr. Levan deserves great credit for making a clinical diagnosis. The color and the location are correct, but such a small lesion did not

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