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August 1961

Monilial Granuloma with Hypergammaglobulinemia: Treatment with Amphotericin B and Dermabrasion

Author Affiliations


Arch Dermatol. 1961;84(2):192-198. doi:10.1001/archderm.1961.01580140018002

Among the many unusual and severe infections due to Candida albicans that have been reported are thrush of the umbilical cord (intrauterine infection), esophageal involvement without oral involvement, infection of the conjunctiva and cornea, intraocular lesions after cataract surgery, peritonitis, empyema, and monilial cystitis.1-7 In 1950 Hauser and Rothmans reviewed the world's literature and added an additional case of monilial granuloma, a peculiar and often fatal form of candidiasis. Since that report 4 more cases have been recorded, making a total of 18 in all. This paper reports a case of monilial granuloma having the unique features of hypergammaglobulinemia and an associated Microsporum audouini infection.

Report of a Case  A 12-year-old Negro girl presented with a bizarre eruption involving face, scalp, fingernails, mouth, and arms of about 8 years' duration (Fig. 1). The history was not felt to be entirely reliable, but the parents stated that the mouth

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