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Article
August 1961

Treatment of Granuloma Inguinale with Triacetyloleandomycin: Report of a Case

Author Affiliations

CARACAS, VENEZUELA

From the Department of Dermatology, Vargas Hospital (Dr. Kerdel-Vegas, Assistant Professor; Dr. Convit, Associate Professor; and Dr. Soto, Resident Physician).

Arch Dermatol. 1961;84(2):248-255. doi:10.1001/archderm.1961.01580140074009
Abstract

Granuloma inguinale (granuloma venereum, donovanosis), a disease of the skin and subcutaneous tissues, usually of the genital region, and seen mainly among the darkskinned races, is still endemic in some parts of the world including southern United States. The etiology, epidemiology, diagnosis, differential diagnosis, and clinical course have been well reviewed by Greenblatt and associates1 and Thambiah.2

Penicillin has proved ineffective, and nonspecific treatment has been generally disappointing and punctuated by relapses. Until the advent of streptomycin, dissemination to other parts of the body, with prolonged disability and even death, resulted directly or indirectly from secondary spread of the lesions from the primary focus. Medina and Alarcón3 reported a fatal case in a white woman of granuloma inguinale with large granulomatous ulcerations on the external genitals, and invasion of vaginal mucosa and uterine cervix. Despite antibiotic treatment, ulcerous lesions on the left leg and an intestinal fistula

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